新法合成头孢他定中间产品

Synthesis of Ceftazidime Intermediate by New Method

目的:提高α-溴代异丁酸叔丁酯的收率。方法:采用新工艺合成α-溴代异丁酸叔丁酯。结果:优化反应条件,减小了溴的用量,改善操作环境,减少了三废污染。结论:最终收率达到88．1％。

Objective： To improve the yield of α- bromo - iso - butyric acid - tert - butyl ester. Methods： To adopt a new process to s.vnthesis of α- bromo - iso - butyric acid - tert - butyl ester Results： To optimize the reaction conditions, reduce the usage of bromine, improve the operation environment and reduce the contamination of waste. Conclusion： the final yield is 88.1%.