吡啶催化合成乙酰水杨酸的研究

Synthesis of Acetyl Salicylic Acid with Pyridine as Catalyst

用吡啶催化剂,以水杨酸和乙酸酐为原料合成乙酰水杨酸。结果表明,当水杨酸用量为2.0g,乙酸酐用量为5.9mL,吡啶用量为水杨酸质量的5%时,80℃反应30min,纯化乙酰水杨酸收率可达80.2%,且吡啶是合成乙酰水杨酸的优良催化剂。

Acetyl salicylic acid was synthesized from salicylic acid and acetic anhydride catalysed by pyridine. The target compound could be obtained in 80.2% yield after heating of the reaction mixtures（salicylic acid 2.0g, acetic anhydride 5.9mL, Pyridine 5%（ wt% of salicylic acid））, 80℃ reaction for 30 min. It was proved that salicylic acid was synthesized in high yield with the catalysis of pyridine