血清前列腺特异性抗原水平在鉴别前列腺疾病中的临床应用

Clinical application of total prostate specific antigen in distinguish of prostate diseases

①目的探讨总前列腺特异性抗原、游离前列腺特异性抗原及两者比值在良性前列腺增生和前列腺癌鉴别诊断中的临床意义。②方法采用电化学发光法测定30例健康体检者,28例良性前列腺增生患者和20例前列腺癌患者血清总前列腺特异性抗原、游离前列腺特异性抗原,并计算其比值。③结果正常健康对照组、良性前列腺增生组和前列腺癌组总前列腺特异性抗原依次为(1.49±0.58)、(11.12±6.98)和(12.32±4.73)μg/L,游离前列腺特异性抗原依次为(0.31±0.10)、(1.06±0.52)和(1.25±0.41)μg/L,3组比值依次为0.22±0.05、0.11±0.05和0.08±0.02。前列腺增生组和前列腺癌组游离前列腺特异性抗原和两者比值差异有显著性(P<0.05)。④结论联合应用总前列腺特异性抗原、游离前列腺特异性抗原及两者比值可用于鉴别前列腺增生和前列腺癌。

Objective To eraluate the clinical application of total prostate specific antigen（ t - PSA） , free PSA（ f- PSA） and f- PSA to t - PSA ratio in the differential diangnosis of prostate cancer （Pca） and benign prostate hyperplasia （BPH）. Methods By using electrochemiluminoimmunoassay , 30 healthy cases,28 BPH cases and 20 Pca cases were exam- ined to detect the serum levels of f- PSA and t - PSA, f - PSA/t - PSA ratio was calculated. Results t - PSA of groups with Pca , BPH and heathy persons were （ 12.32 ± 4.73 ）, （ 11.12 ± 6.98 ） and （ 1.49 ± 0.58 ） ug/l, f - PSA were （ 1.25 ± 0.41 ） , （ 1.06 ± 0.52 ） and （ 0.31 ± 0.10） ug/l , t - PSA/f - PSA were 0.08 ± 0.02, 0.11 ± 0.05 and 0.22± 0.05. f - PSA and f - PSA/t - PSA ratio of groups with Pca and BPH have significant difference（ P 〈 0.05 ）. Conclusion f - PSA and f- PSA/t - PSA ratio can be used to differentially diagnose Pca 和 BPH.