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他汀类药物对血管新生作用及机制的研究 被引量:9

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摘要 小剂量他汀类药物能促进骨髓来源内皮祖细胞的动员和分化,提高内皮祖细胞的数量和分化、迁移能力,促进缺血组织血管新生。小剂量他汀类药物可能通过磷脂酰肌醇-3激酶(PI-3K)/苏氨酸激酶(Akt)旁路增加内皮型一氧化氮合酶的表达,从而动员内皮祖细胞。而大剂量他汀类药物可抑制血管新生。
作者 周卿 陈书艳
出处 《国际心血管病杂志》 2006年第1期45-48,共4页 International Journal of Cardiovascular Disease
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