联用尼美舒利对5-氟尿嘧啶在大鼠体内药代动力学的影响

Effect of nimesulide on pharmacokinetics of 5-fluorouracil in rats

目的分析尼美舒利(Nim)对5-氟尿嘧啶(5-Fu)在大鼠体内药代动力学参数的影响。方法用反相高效液相色谱法精密检测血浆中5-Fu的浓度,研究单用5-Fu及联用Nim后的药代动力学变化。结果联用Nim后,5-Fu的药时曲线下面积、最大血药浓度增大,清除率下降、达峰时间延迟、消除相半衰期增加。结论联用Nim后可使5-Fu进入血循环总药量增加,在体内吸收减慢、消除延缓,作用时间延长。为两药联用后人体药代动力学研究提供参考。

Objective： To study the effect of nimesulide （Nim） on the pharmacokinetics of 5-fluorouracil （5-Fu） in rats. Methods： The concentration of 5-Fu in the plasma of rats was detected with reverse phase high performance liquid chromatography （RP-HPLC）. Results： After administration of Nim, the area under the curve （ AUC）, maximum plasma concentration （Cmax） , half life of elimination, and total amount of 5-Fu in blood circulation increased, and the clearance rate （Clr） and peak time （Tpeak） decreased. Condusion： Compared with administration of 5-Fu alone, administration of 5-Fu combined with Nim could increase the total amount of 5-Fu in blood circulation, slow down the absorption of 5-Fu, and prolong the action time of 5-Fu. This study provides a good reference for combined administration of 5-Fu and Nim in the pharmaeokinetic study.