摘要
建立了一个在质子性溶剂中经由o-quinonemethide中间体的trans-hexahydrocannabinol的简便合成方法.用对甲苯磺酸为催化剂,加热回流resorcinol衍生物和citronellal之间偶联产物的甲醇溶液,酚的脱保护、o-quinonemethides的生成以及分子内狄尔斯-阿尔德环加成反应一步完成,产率为93%～95%.
A simple synthesis of trans-hexahydrocannabinol via an o-quinonemethide in protic solvent was established. The methanol solution of coupling product of a resorcinol derivatives and citronellal was refluxed in the presence of p-methylbenzenesulforic acid as an catalyst, the deprotection of phenols, production of o-quinonemethides and intramolucular Diels-Alder cycloaddition reaction took place in one step, in 93%-95% yield.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2006年第17期1843-1846,共4页
Acta Chimica Sinica
