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PPAR-γ在高血压与左室重构中的作用

The Actions of PPAR-γ in the Development of Hypertension and Left Ventricular Remodelling
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摘要 胰岛素抵抗/高胰岛素血症与肾素-血管紧张素系统在高血压的发生、发展中起着举足轻重的作用。血管紧张素Ⅱ的大部分生理作用都是通过血管紧张素Ⅱ1型受体介导的。过氧化物酶体增殖物激活受体-γ不仅调节糖、脂代谢,还调控着血管紧张素Ⅱ1型受体mRNA的表达,参与高血压和左室重构的发生、发展。 Insulin resistance / hyperinsulinemia and the renin-angiotensin system play an important role in the development of hypertension. Peroxisome proliferator-activated receptors （PPAR-γ） regulates not only the metabolism of glucide and lipid, but also the expression of angiotensin Ⅱ type 1 receptor, which mediates the major action of anglotensin Ⅱ , and is involved in the development of hypertension and left ventricular remodelling.
作者 钟文 陈晓平
机构地区 四川大学华西临床医学院 四川大学华西医院心内科
出处 《心血管病学进展》 CAS 2006年第5期579-582,共4页 Advances in Cardiovascular Diseases
关键词 PPAR-Γ 高血压 左室重构 PPAR-γ hypertension left ventricular remodelling
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献29

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二级参考文献38

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心血管病学进展
2006年 第5期

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