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肥胖并发高血压的机制及治疗进展 被引量：8

Progress in Research into the Mechanism and Treatment of Obesity Hypertension
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摘要 肥胖是高血压发生中一个主要的危险因素,现综述肥胖并发高血压机制、治疗等方面的研究进展。 Obesity is a major risk factor in the development of hypertension. This article summarizes research into the mechanism and treatment of obesity hypertension.
作者 梁晓慧 徐新娟
机构地区 新疆医科大学第一附属医院心血管专科医院高血压科
出处 《心血管病学进展》 CAS 2006年第5期608-611,共4页 Advances in Cardiovascular Diseases
关键词 肥胖并发高血压 交感神经系统 肾素-血管紧张素-醛固酮系统 瘦素 胰岛素抵抗 obesity hypertension sympathetic nervous system renin-angiotensin-aldosterone system leptin insulin resistance
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献24

  • 1Pausova Z,Deslauriers B,Gaudet D,et al.Role of tumor necrosis factor-α gene locus in obesity and obesity-associated hypertension in French Canadians[J].Hypertension,2000,36:14-19.
  • 2Antic V,Kiener-Belforti F,Tempini A,et al.Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits[J].Am J Hypertens,2000,13(5pt1):556-559.
  • 3Boustany CM,Bharadwaj K,Daugherty A,et al.Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension[J].Am J Physiol Regul Integr Comp Physiol,2004,287(4):943-949.
  • 4Considine RV,Sinha MK,Heiman ML,et al.Serum immunoreactive-leptin concentrations in normal weight and obese humans[J].N Engl J Med,1996,334:292-295.
  • 5黎明,吴从愿,詹志伟,杨静,张葵,李晓光,甘利虹,纪宝华.血清瘦素水平与原发性高血压的相关性研究[J].中华医学杂志,2003,83(12):1058-1061. 被引量：31
  • 6Agata J,Masuda A,Takada M,et al.High plasma immunoreative level in essential hypertension[J].Am J Hypertens,1997,10:1171-1174.
  • 7Uckaya G,Ozata M,Sonmez A,et al.Plasma leptin levels strongly correlate with plasma renin activity in patients with essential hypertension[J].Horm Metab Res,1999,31:435-438.
  • 8Adamczak M,Kokot F,Wiecek AW.Relationship between plasma renin profile and leptinaemia in patients with essential hypertension[J].J Hum Hypertens,2000,14:503-509.
  • 9Beltowski J,Jamroz-Wisniewska A,Borkowska E,et al.Up-regulation of renal Na^+-K^+-ATPase:the possible novel mechanism of leptin-induced hypertension[J].Pol J Pharmacol,2004,56:213-222.
  • 10Ludwig DS,Tritos NA,Mastaitis JW,et al.Melanin-concentrating hormoneoverexpression in transgenic mice leads to obesity and insulin resistance[J].JClin Invest,2001,107:379-386.

二级参考文献14

  • 1Ahima RS, Flier JS. Leptin. Annu Rev Physiol, 2000, 62: 413-437.
  • 2Hall JE, Hildebrandt DA, Kuo J. Obesity hypertension: role of leptin and sympathetic nervous system. Am J Hypertens, 2001, 14: 103S-115S
  • 3Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension, 1998, 31: 409-414.
  • 4Sheu WH, Lee WJ, Chen YT. High plasma leptin concentrations in hypertensive men but not in hypertensive women. J Hypertens, 1999,17: 1289-1295.
  • 5Suter PM, Locher R, Hasler E, et al. Is there a role for the ob gene product leptin in essential hypertension? Am J Hypertens, 1998,11: 1305-1311.
  • 6Takizawa H, Ura N, Saitoh S, et al. Gender differences in the relationships among hyperleptinemia, hyperinsulinemia, and hypertension. Clin Exp Hypertens, 2001, 23: 357-68.
  • 7de Courten M, Zimmet P, Hodge A, et al. Hyperleptinaemia: the missing link in the, metabolic syndrome? Diabet Med, 1997,14: 200-208.
  • 8Hu FB, Chen C, Wang B, et al.Leptin concentration in relation to overall adiposity, fat distribution, and blood pressure in rural Chinese populaation. Int J Obes Relat Metab Disord, 2001,25:121-125.
  • 9Kuo JJ, Jones OB, Hall JE. Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin.Hypertension. 2001, 37: 670-676.
  • 10Mark AL, Correia ML, Rahmouni K, et al. Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens, 2002, 20: 1245-1250.

共引文献45

同被引文献91

引证文献8

二级引证文献94

心血管病学进展
2006年 第5期

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