期刊文献+

E-选择素与心肌缺血再灌注损伤 被引量:2

E-Selectin and Ischemia-Reperfusion Injury in the Heart
下载PDF
导出
摘要 E-选择素是血管内皮细胞合成的一种糖蛋白分子,介导白细胞与内皮细胞的黏附过程,与炎症或缺血再灌注损伤时白细胞的募集有关。心肌缺血再灌注损伤时E-选择素表达明显增加,降低E选-择素的表达或阻断其作用可减轻缺血再灌注损伤。 E-selectin is a kind of glycoprotein expressed in the vascular endothelial cell. E-selectin may play an important role in the adhesion of leukocytes to the vascular endothelium and is related to the recruitment of leukocytes during ischemia-reperfusion injury in the heart. The expression of E-selectin can be increased significantly during ischemia-reperfusion injury. A protective effect can be obtained by blocking the expression of ligands of E-selectin.
机构地区 潍坊医学院
出处 《心血管病学进展》 CAS 2006年第5期637-639,共3页 Advances in Cardiovascular Diseases
关键词 E-选择素 心肌缺血再灌注损伤 E-selectin ischemia-reperfusion injury
  • 相关文献

参考文献18

  • 1Collins T,Williams A,Johnston GI,et al.Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1[J].J Biol Chem,1991,266(4):2466-2473.
  • 2Whitley MZ,Thanos D,Read MA,et al.A striking similarity in the organization of the E-selectin and beta interferon gene promoters[J].Mol Cell Biol,1994,14 (10):6464-6475.
  • 3Read MA,Whitley MZ,Gupta S,et al.Tumor necrosis factor-α induced E-selectin expression is activated by the nuclear factor-κB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways[J].J Biol Chem,1997,272(5):2753-2761.
  • 4Chiu JJ,Lee PL,Chen CN,et al.Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor-α in endothelial cells[J].Arterioscler Thromb Vasc Biol,2004,24(1):73-79.
  • 5Cockerill GW,Huehns TY,Weerasinghe A,et al.Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation[J].Circulation,2001,103(1):108-112.
  • 6Tiemeyer M,Swiedler SJ,Ishihara M,et al.Carbohydrate ligands for endothelial-leukocyte adhesion molecule 1[J].PNAS,1991,88(4):1138-1142.
  • 7Shen I,Verrier ED.Expression of E-selectin on coronary endothelium after myocardial ischemia and reperfusion[J].J Card Surg,1994,9(suppl 3):437-441.
  • 8Weyrich AS,Buerke M,Albertine KH,et al.Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium[J].J Leukoc Biol,1995,57(1):45-55.
  • 9Jones SP,Trocha SD,Strange MB,et al.Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury[J].Am J Pysiol Heart Circ Physiol,2000,279(5):H2196-H2201.
  • 10Ioculano M,Altavilla D,Squadrito F,et al.Tumour necrosis factor mediates E-selectin production and leukocyte accumulation in myocardial ischaemia-reperfusion injury[J].Pharmacol Res,1995,31(5):281-288.

二级参考文献2

共引文献13

同被引文献24

引证文献2

二级引证文献29

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部