摘要
E-选择素是血管内皮细胞合成的一种糖蛋白分子,介导白细胞与内皮细胞的黏附过程,与炎症或缺血再灌注损伤时白细胞的募集有关。心肌缺血再灌注损伤时E-选择素表达明显增加,降低E选-择素的表达或阻断其作用可减轻缺血再灌注损伤。
E-selectin is a kind of glycoprotein expressed in the vascular endothelial cell. E-selectin may play an important role in the adhesion of leukocytes to the vascular endothelium and is related to the recruitment of leukocytes during ischemia-reperfusion injury in the heart. The expression of E-selectin can be increased significantly during ischemia-reperfusion injury. A protective effect can be obtained by blocking the expression of ligands of E-selectin.
出处
《心血管病学进展》
CAS
2006年第5期637-639,共3页
Advances in Cardiovascular Diseases