血栓前体蛋白对血栓形成性疾病的诊断价值

Diagnostic Value of TpP in Vascular Thrombotic Diseases

【目的】探讨血浆中血栓前体蛋白(TpP)的检测对急性心肌梗死(AMI)、急性脑梗死(ACI)、不稳定心绞痛(UA)、弥漫性血管内凝血(DIC)的临床诊断意义。【方法】利用酶联免疫方法(ELISA)定量测定50例健康对照者、33例AMI患者发病6 h前后、28例UA、18例ACI治疗前后、17例DIC各期血浆中TpP的浓度。【结果】AMI患者发病6 h内、ACI治疗前后、DIC各期血浆TpP水平与健康对照组相比较有显著性差异(P<0.01),AMI发病6h后及UA与健康对照组相比差异无显著性(P>0.05);AMI患者发病6 h前后比较、ACI患者治疗前和治疗后7 d比较有显著性差异(P<0.01);DIC患者消耗性低凝期、纤溶亢进期与高凝期、治疗后期比较均有显著性差异(P<0.01)。【结论】TpP对血栓形成性疾病的诊断有一定的价值,可作为AMI、ACI、DIC的早期诊断指标,并且对ACI和DIC的病程发展、疗效评估有较积极的意义。

[Objective]To discuss the clinical value of plasma thrombus precursor protein （TpP） in the di agnosis of acute myocardial infarction （AMI） acute cerebrovascular infarction （ACI）; unstable angina （UA） and disseminated intravascular coagulation （DIC） . [Methods]The concentrations of TpP in 50 healthy people, 33 patients with AMI before or after falling ill in 6 hours,28 patients with UA,18 patients with ACI before or after treatment and 17 patients with DIC were measured by enzyme linked immunosorbent assay （ELISA）. [Results]There were significant differences in patients with AMI failing ill in 6 hours, patients with ACI before or after treatment, patients with DIC during the four periods compared with the healthy people. There was no significant difference in the patients with AMI 6 hours after falling ill and patients with UA compared with the healthy people. There were significant differences in patients with AMI before falling ill compared with af ter falling ill in 6 hours, patients with ACI before treatment compared with after treatment in 7 days. [Conclusion]There is diagnosis value of TpP in thrombosis diseases, it can be the earlier diagnostic index of AMI, ACI and DIC, provide more referable positive value for the treatment and prognosis of ACI and DIC.