摘要
IgA肾病是肾小球系膜病变的一个特殊类型,基因多态性可能与IgA肾病的产生和发展有关,不同基因型的病人其临床表现或病理类型也可能存在差异,而该病可能与多种基因有关,研究较多的有:肾素血管紧张素系统基因多态性、子宫球蛋白基因多态性、MBP多态性、细胞因子多态性、TGF-β1的基因多态性等。目前国内外学者的研究结果还不完全一致,这是由于基因多态性与种族、性别有关,本文仅对已有研究作一综述。
IgA nephropathy is a special type of glomerular mesangial disease. Gene polymorphisms may be related to the onset and development of IgA nephropathy. Patients with different gene types may have different manifestations and pathological types. More than ten gene types may be related to the disease. Many reseachers focused their studies on RAS ( Renal Angiotensin System ), UG ( Uteroglobin ), MBP ( Mannose-Binding Protein ), CK (Cytokine) and TGF-β1 (Transforming Growth Factor-betal ), but the results were not identical to each other because of the races and genders of the investigated patients.
出处
《国际免疫学杂志》
CAS
2006年第5期282-286,共5页
International Journal of Immunology
基金
上海市自然科学基金项目(04ZR14005)
关键词
IGA肾病
基因
多态
IgA nephropathy, Gene, Polymorphism