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DNA疫苗与肿瘤免疫治疗 被引量：5

DNA vaccines and cancer immunotherapy
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摘要 DNA疫苗因其能诱发有效及持久的免疫反应而被广泛应用于恶性肿瘤的免疫治疗。已构建出多种肿瘤DNA疫苗,包括TAAs全长DNA疫苗、TAAs表位DNA疫苗、肿瘤融合DNA疫苗。肿瘤DNA疫苗可以激发肿瘤特异性的细胞/体液免疫反应及延长实验动物的生存期。肿瘤DNA疫苗在动物试验中的有效性为其在临床治疗中的应用提供了理论依据。 Because of generating strong and lasting immune responses, DNA vaccines have been used in a wide range of cancer immunotherapy. In recent veals, various strategies for cancer DNA vaccines, including lull-length tumor associated-antigen （TAAs） vaccines, epitope-specific vaccines, and fusion gene vaccines, have been developed. DNA vaccines can activate all anus of the immune system and prolong the life span of experimental models. These results provide a platform for prompting the execution of a number of clinical trials of DNA vaccines for cancer.
作者 罗晨 李官成
机构地区 中南大学湘雅医学院肿瘤研究所
出处 《国际病理科学与临床杂志》 CAS 2006年第4期333-335,339,共4页 Journal of International Pathology and Clinical Medicine
基金 湖南省自然科学基金(04JJ3098)
关键词 DNA疫苗 免疫治疗 肿瘤相关抗原 DNA vaccine immunotherapy tumor associated antigen
分类号 R730.5 [医药卫生—肿瘤]
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参考文献20

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国际病理科学与临床杂志
2006年 第4期

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