葡萄糖透析液与腹膜纤维化研究进展

Advance of glucose-based dialysate and peritoneal fibrosis

使用葡萄糖透析液进行腹膜透析透是治疗终末期肾脏病的有效措施之一。但近年来大量临床研究发现,透析液中葡萄糖对腹膜的结构和功能有重要影响,导致腹膜纤维化,超滤失败,最终放弃腹膜透析。了解透析液中葡萄糖对腹膜的影响及潜在的治疗策略具有十分重要的意义。

Peritoneal dialysis（PD） using glucose-based dialysate is one of the effective treatment for patients with end-stage renal disease. But many clinical investigations show that exposure of the peritoeal membrane to high glucose concentrations contributes to both structural and functional changes in thedialyzed peritoneal membrane. In the end,patients drop out from PD due to peritoneal fibrosisand ultrafiltration failure over time on dialvsis. So it is very important to know adverse effects of glucose in PD solutions and potential therapeutic interventions.