急剧弯曲DNA柔韧性的研究进展

THE FLEXIBILITY OF SHARPLY BENT DNA

基因调控,核小体和病毒的包装行为都会涉及DNA的急剧弯曲成环。DNA分子的环化是研究其本身柔韧性的主要方法。目前已经发展出很多研究DNA环化的模型,其中WLC(worm-likechain)模型较为成熟。近年来,在DNA环化的重要参数、影响因素以及DNA急剧弯曲成环的理论研究等诸多方面都有了新进展。

DNA sharply bending is essential for gene regulation as well as the package of nucleosomes and viruses. The major process to study DNA instinctive flexibility is DNA cyclization assay. Up to date, many new models have been developed for DNA cyclization research. And the best one is the worm-like chain model. With the deep development in this field, there are lots of advanced progress in important parameters about DNA cyclization assay, factors that influence DNA cyclization and DNA sharp bending field.