1Kino T, Hatanaka H, Hashimoto M. FK506 a novel immunosuppressant isolated from a streptomyces fermentation isolation and biological characteristics [ J ]. J Antibiot 1987 ;40:1249-1255.
2S1oper CM, Powell RJ, Dua HS. Tacrolimus (FK506) in the management of high-risk corneal and limbal grafts [ J]. Ophthalmology 2001; 108(10): 1838-1844.
3Rao SK, Rajagopal R, Fogla R, Sitalakshmi G, Padmanabhan P. Llmbal allografting using FK-506[J]. Br J Ophthalmol 1999 ;83(12): 1409-1410.
4Reis A, Reinhard T, Sundmacher R, Braunstein S, Godehardt E. Mycophenolate mofetil and FK506: two novel immunosuppressants in murine corneal grafts[ J]. Transplant Proc 1998;30(8) :4344-4347.
5Kobayashi C, Kanai A, Nakajima A, Okumur K. Suppreddion of corneal graft refection in rabbits by a new immunosuppressive agent FK506[J]. Transplant Proc 1989;21(1):3156.
6Hatanaka H, Kino T, Miyata S, et al. FR-900520 and FR-900523, novel immunosuppressants isolated from a streptomyces Ⅱ. Fermantation,isolation and physico-chemical and biological characteristics [ J ]. J Antibiot, 1988,11: 1592 - 1601
7Pleyer U, Lutz S, Jusko W J, et al. Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye [ J ]. Invest Ophthalmol Vis Sci, 1993,34( 8 ): 2737 - 2742
8Quintanar-Guarrero D. Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymer[J]. Drug Develop Indust Pharm, 1998,25 ( 12 ): 1115 - 1123
9Joshi A. Microparticulates of ophthalmic drug delivery [ J ]. JOcul Pharmacol, 1994,10 ( 1 ): 29 - 45
10Kimura H,Ogura Y. Biodegradable polymers for ocular drug delivery[J].Ophthalmologica ,2001,215 ( 3 ): 143 - 155
9Lam H, Dana MR. Comeal graft rejection [J]. Int OphthalmolClin,2009,49(1) :31-41.
10Mulligan MS, Warner RL, McDuffie JE, et al. Regulatory role ofTh-2 cytokines,IL-10 and IL-4,in cardiac allograft rejection[J].Exp Mol Pathol,2000,69(1) :l-9.
