摘要
目的:研究慢性胃病患者口腔中是否存在幽门螺杆菌(Hp),并分析胃病患者牙周状况与幽门螺杆菌的关系。方法:依据特异的尿素酶C基因和cag A基因设计引物,建立聚合酶链反应(PCR)方法。检测65例慢性胃病患者不同牙位龈上和龈下菌斑中的Hp。结果:65例慢性胃病患者胃黏膜标本中,PCR检测阳性标本58例(89.3%),龈下菌斑Hp阳性率(47.7%),高于龈上菌斑中的Hp阳性率(26.2%)。牙周袋深度(PD)≥4 mm部位菌斑中Hp检出率显著高于PD<4mm的部位(P<0.05)。结论:口腔Hp是慢性胃病患者Hp感染的重要来源。
Objective: To investigate the prevalence of Helicobacter pylori(Hp) in the oral cavity of gastritis patients, and analyze the relationship of the patients' chronic periodontal disease and Hp. Method: A polymerase chain reaction (PCR) assay with oligonucleotide primers homologous to a portion of the urease C and cytotoxin-associated gene A (cag A) of Hp was used to test for the presense of Hp in dental plaque. 65 gastric disease patients were recruited to detect Hp in supra- and subgingival plaque. Result. 65 chronic gastritis patients, 58 patients (89.3 % ) had at least one Hp positive dental plaque sample. The Hp positive rate was significantly higher in supragingival plaque (47.7 % ) than in subgingival plaque (26.2%). The prevalence of Hp was positively correlated with probing depth. Conclusion. Oral Hp infection may be an important source of gastric Hp infection.
出处
《临床口腔医学杂志》
2006年第9期524-525,共2页
Journal of Clinical Stomatology
基金
泰安市科技局基金(泰科计字[2002]9号)