运动神经元病患者的记忆功能研究

Study of memory function in patients with motor neuron disease

目的观察运动神经元病(motor neuron disease,MND)患者是否存在记忆功能障碍;并研究患者的病程对其记忆功能的影响。方法对比分析了32例MND患者与60例正常对照的临床记忆量表评分,并比较不同病程的MND患者的记忆功能评分。结果MND患者记忆商、临床记忆量表总等值量表分、指向记忆等值量表分、无意义图形再认等值量表分评分均明显低于对照组(P<0.05),且不同病程的MND患者临床记忆量表各项评分比较无显著性差异(P>0.05)。结论MND患者大多存在记忆障碍,提示MND存在运动区域以外的脑组织受累。MND患者的记忆障碍与病程长短无明显关系。

Objective To observe whether there is memory deficits in patients with motor neuron disease （MND） and investigate the influence of the course of the disease. Methods This research contrasted the result of 32 MND patients and 60 normal controls tested with clinical memory scale ;at the same time ,compared the patients＇ scores of clinical memory scale in different courses of disease. Results As compared with the normal controls, memory quotient （MQ）, equivalent scale scores of the total scale and pointing memory and insignificant figure recognition items were significantly decreased in patients with MND（P〈0.05）. However,there was no significant difference in patients＇ scores of clinical memory scale in defferent courses of disease（P〉0.05）. Conclusion There is memory deficits in patients with MND,suggesting neuronal degeneration extends over the motor system. The course of disease has no correlation with the score of memory deficits.