硝普钠与乌拉地尔治疗顽固性心力衰竭的临床观察

Effects between Nipruton and Urapidil for Treatment of the Stubborn Congestive Heart Failure

目的观察硝普钠与乌拉地尔治疗顽固性心力衰竭的疗效。方法对42例顽固性心力衰竭患者在综合治疗的基础上应用硝普钠与乌拉地尔治疗顽固性心衰,疗程7-10d。结果乌拉地尔组总有效率(90．9％)显著高于硝普钠组(80％);两组治疗前后的心功能状况左心室射血分数(LVEF)、左心室短轴缩短率(FS)、舒张早期最大充盈速度(E)与舒张晚期最大充盈速度(A)的比值(E／A)、每搏输出量(SV)、心输出量(CO)心脏指数(CI)、及心率、呼吸频率均可得到明显的改善。但乌拉地尔可以更明显地改善心功能。结论在综合治疗的基础上应用乌拉地尔治疗顽固性心力衰竭可以更明显地改善顽固性心力衰竭心功能,且具有更高的临床有效率而无明显的毒副作用。

Objective To compare the effects between Nipruton and Urapidil for treating the stubborn congestive heart failure. Methods After treated by routine measure ,42 serious CHF patients were randomized into two groups ;22 to Urapidil group,20 to Nipruton group for the advanced therapy between 7 to10 days. Results The total efficient rate in Urapidil group （ 90.9% ） is more higher than Nipruton group （ 80% ）. The index of heart function such as LVEF,FS,E/A ,SV ,CO ,CI ; Heart rate,respiratory rate,Blood Pressure can improve in both groups after the therapy（ P 〈0.05 ） , but the effects of Urapidil group is more higher than Nipruton group （ P 〈 0.05 ）. Conclusion Urapidil can be more efficient in treating stubborn congestive heart failure than Nipruton and have no more side effects.