摘要
目的观察氯沙坦治疗充血性心力衰竭(CHF)的临床疗效。方法 142例经常规洋地黄、利尿剂、血管扩张剂等治疗效果欠佳的CHF患者,给予口服氯沙坦(Losartan)50 mg～100 mg/ d,治疗8周。观察治疗前后心率、心胸比、血压、左室舒张末期内径、左室射血分数以及心功能的变化。结果治疗后心率、血压、心胸比以及左室舒张末期内径与治疗前比较均明显下降(P<0．05)。左室射血分数增加(P<0．01),心功能改善1—2级,药物副作用少,患者耐受性好。结论氯沙坦治疗CHF疗效好,副作用较少,是治疗慢性心率衰竭新的较好的治疗药物。
Objective To observe the effect of Losantan in treating patients with congestive heart failure. Method A hundred and forty-two patients with heart failure, who had unsatisfactory results under conventional digitals, diuretics, vasodilators therapy, were given Losantan 50 - 100mg orally once a day for 8 weeks. The changes of heart rate （HR） , blood pressure （BP） , cardiothoracic ratio, left ventrlcular end diastolic diameter （LVEDD） , left ventricular ejection fraction （LVEF） , and cardiac function （NYHA） were observed. Result After 8 weeks therapy, HR, BP, cardiothoracil ratio and LVEDD all decreased significantly （P 〈 0. 05, P 〈 0.01 ） ; LVEF increased （ P 〈 0.01 ） ; cardiac function （NYHA） improved 1 - 2 grade. Losartan had few adverse effects and patients＇ tolerance was good. Conclusion The effect of Losartan entreating patients with congestive heart failure is satisfactory. It has few adverse effects. It appears to be apromising new therapy for patients with chronic heart failure.
出处
《中国分子心脏病学杂志》
CAS
2006年第2期88-89,共2页
Molecular Cardiology of China
