期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基质金属蛋白酶与类风湿性关节炎的研究进展 被引量：6

Progress in Matrix Metalloproteinase and Rheumatoid Arthritis
下载PDF
导出
摘要 基质金属蛋白酶(MMPs)是一组能降解所有细胞外基质的蛋白溶解酶家族,亦是致类风湿性关节炎(RA)不可逆关节损害的主要原因之一。而所有MMPs的活性均可被相应的组织金属蛋白酶抑制剂(TIMPs)所抑制。下调MMPs和(或)上调TIMPs是治疗类风湿性关节炎的重要策略之一。 Matrix metallopruteinases（MMPs） are a family of matrix-degrading enzymes of the extracollular matrix and contribute to inreversible joint destruction. MMPs are all inhibited by tissue inhibitors of matrix metalloproteinase （TIMPs）. Down-regulation of MMPs and/or up-regulation of TIMPs are principal strategies of therapy in rheumatoid arthritis.
作者 刘艳 贾玉杰
机构地区 大连市儿童医院内科 大连医科大学病理生理教研室
出处 《医学综述》 2006年第17期1027-1029,共3页 Medical Recapitulate
关键词 关节炎 类风湿 基质金属蛋白酶 组织金属蛋白酶抑制剂 Arthritis, Rheumatoid Matrix metalloproteinase Tissue inhibitors of metanoproteinase
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献18

  • 1Tetlow LC,Woolley DE.Mast cells,cytokines,and metalloproteinases at the rheumatoid lesion:dual immunolocalisation studies[J].Ann Rheum Dis,1995,54(11):896-903.
  • 2Gravallese EM,Darling JM,Ladd AL,et al.In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium[J].Arthritis Rheum,1991,34(9):1076-1084.
  • 3Li YY,McTiernan CF,Feldman AM.Interplay of matrix metalloproteinases,tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling[J].Cardiovasc Res,2000,46(2):214-224.
  • 4Marchenko GN,Strongin AY.MMP-28,a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors[J].Gene,2001,265 (1-2):87-93.
  • 5Springman EB,Angleton EL,Birkedal-Hansen H,et al.Multiple modes of activation of latent human fibroblast collagenase:evidence for the role of a Cys 73 active-site zinc complex in latency and a "cysteine switch"mechanism for activation[J].Proc Natl Acad Sci U S A,1990,87 (1):364-368.
  • 6Pei D,Weiss SJ.Furin-dependent intracellular activation of the human stromelysin-3 zymogen[J].Nature,1995,375(6528):244-247.
  • 7Murphy G,Atkinson S,Ward R,et al.The role of plasminogen activators in the regulation of connective tissue metalloproteinases[J].Ann NY Acad Sci,1992,667:1-12.
  • 8Saari H,Suomalainen K,Lindy O,et al.Activation of latent human neutrophil collagenase by reactive oxygen species and serine proteases.Biochem[J].Biophys Res Commnn,1990,171(3):979-987.
  • 9Cawston TE.Metalloproteinase inhibitors and the prevention of connective tissue breakdown[J].Pharmacol Ther,1996,70(3):163-182.
  • 10Van Roon JA,Van Roy JL,Gmelig-Meyling FH,et al.Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4[J].Arthritis Rheum,1996,39(5):829-835.

同被引文献59

引证文献6

二级引证文献21

医学综述
2006年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部