摘要
连接黏附分子-1是一细胞黏附分子,免疫球蛋白超家族成员,可作为血小板受体参与血小板的活化;作为配基与淋巴细胞功能性抗原结合,促进白细胞的迁移;并参与碱性成纤维细胞生长因子介导的信号转导途径,增强内皮细胞黏附迁移,促进血管新生。连接黏附分子-1参与动脉粥样硬化发生、发展及转归中与内皮细胞有关的多个作用机制,对探讨动脉粥样硬化的防治具有一定的作用。
Junctional adhesion molecule-1 is a cell adhesion molecule belonging to immunoglobulin superfamily. It can not only act as a platelet receptor to participate in platelet activation,but also act as ligand to bind functional antigen of lymphocyte and then promote leukocytal migration . It also participate in the signal transduction mediated by basic fibroblast growth factor to intensify the adhension and migration of endothelial cell as well as to promote vessel neogenesis . Junctional adhesion molecule-1 contributes to several mechanisms about atherosclerosis in its genesis, development and prognosis related to endothelium, which then will be helpful to study the prevention and treatment of atheroselerosis.
出处
《医学综述》
2006年第17期1029-1030,共2页
Medical Recapitulate
