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8-羟基脱氧鸟苷检测方法的研究进展 被引量：4

The Progress of 8-hydroxy-2′-deoxyguanosine Detecting Method
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摘要 活性氧基团引起的氧化损伤在许多慢性疾病中起着重要作用,8-羟基脱氧鸟苷(8-OHDG)是DNA氧化损伤的修饰产物之一,可以通过高灵敏度、高选择性的检测手段来检测,目前已成为DNA氧化损伤中最常采用的生物标志物。本文主要介绍其来源、检测方法及在医学上的应用。 Oxidative damage from reactive oxygen species including free radicals has been considered to play a vital role in many chronic diseases. 8-hydroxy-2＇-deoxyguanosine（8-OHDG） is one of modified products resulting from DNA oxidative day,rage, which can be detected by methods with high sensitivity and high selectivity, and is a common used biomarkcr in detecting DNA oxidative damage. This paper introduces the source, detecting method and apnication of 8-OHDG.
作者 刘胜林
机构地区 天津西青医院检验科
出处 《医学综述》 2006年第17期1073-1074,共2页 Medical Recapitulate
关键词 8-羟基脱氧鸟苷 DNA氧化损伤 检测 8-hydroxy-2＇-deoxyguanosine DNA Oxidative damage Detection
分类号 R331 [医药卫生—人体生理学]
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参考文献20

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二级参考文献85

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医学综述
2006年 第17期

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