布洛芬微晶体在口腔崩解片中的应用

Disintegration behavior of ibuprofen microcrystal from orally disintegrating tablets

目的:改善口腔崩解片干粉压片工艺中药物的可压性、流动性、黏冲性,提高崩解片的崩解速度。方法:以布洛芬为模型药物,利用溶剂一非溶剂法改变其结晶形态,获得5种不同的微晶体,并用扫描电镜(SEM)和X衍射仪(XRD)表征。通过各晶体的压片工艺性能测试及压片后的崩解实验,优选出性能良好的晶体,并对其压制的崩解片进行了体外溶出性能的测定。结果:优选出的微晶体具有良好的可压性、流动性和抗黏冲性能,压片后崩解时限大大缩短,溶出度也有一定的提高。结论:优选出的布洛芬微晶体改善了口腔崩解片的整体性能。

Objective： To improve the tablet disintegration by selecting ap of drug powders to prepare orally disintegrating tablets. Methods： Five types of propriate microcrystal buprofen microcrystal were made by solvent-nonsolvent crystallization technique. The microcrystal was characterized by scanned electronic microscopy （SEM） and X-ray detector （XRD）, respectively. The optimal crystals were obtained by the feature tests of compressibility and flowability and the dissolution test of the orally disintegrating tables. Results： The optimal microcrystal had better compressibility, flowability and resistance to sticking to a die well. The orally integrating tablets made of the optimal microcrystal showed improved dissolution and solubility. Conclusion ： The optimal microcrystal improved the integrated behavior of ibuprofen orally disintegrating tablet.