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114例硫普罗宁不良反应文献分析 被引量:10

Literature analysis of adverse drug reactions of tiopronin
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摘要 目的:探讨硫普罗宁不良反应的一般规律及特点,为临床合理用药提供参考。方法:对1999-2005年国内公开报道的114例硫普罗宁所致不良反应按患者性别、年龄、既往不良反应史、给药途径、临床表现、处理方法等分类进行统计分析。结果:76.32%为男性患者,39.29%的患者既往无药物不良反应史,94.74%的患者通过静脉给药,79.82%的不良反应出现在用药过程中,其中99.12%的患者治愈或好转,1例死亡。结论:硫普罗宁引起的不良反应临床表现呈多样性,以过敏反应为主,如处理适当基本能痊愈,但选用该药时仍应考虑性别、年龄、不良反应史、给药速度与浓度等相关因素,合理用药。 Objective: To provide a rationale of the pharmacotherapy of tiopronin by characterizing the adverse drug reactions (ADRs) of tiopronin. Methods: 114 ADRs reports were pooled and statistically analyzed from domestic literatures from 1999 to 2005 with regard of patients' gender, age, ADR history, route of medication, clinical manifestation and treatment actions. Results : Most of patients experiencing ADRs were male, accounting for 76.32%. The patients who had no ARD histories occupied by 39.29% The incidence of ADRs due to intravenous administration was 94.74%. The patients experi- enced ADRs of 79.82% when they simultaneously administered tiopronin, of which 99. 12% of those ADRs were recovered or improved after other medical interventions. One death report was submitted. Most of ADRs were categorized as allergic reaction. Conclusion: Several factors should be taken into consideration when tiopronin is prescribed, including gender, age, ADR history and route of medication.
出处 《中国新药杂志》 CAS CSCD 北大核心 2006年第16期1403-1405,共3页 Chinese Journal of New Drugs
关键词 硫普罗宁 药物不良反应 合理用药 tiopronin adverse drug reaction rational administration
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