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多肽蛋白类药物的长效注射微球突释控制技术研究进展 被引量：6

Progress of Controlling Strategies for Burst Release of Sustained-release Injectable Microspheres Loaded with Proteins
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摘要 综述了多肽蛋白类药物长效注射微球突释控制技术的研究进展。探讨了药物结构修饰、载体材料性质、添加剂、制备工艺、微球粒径及载药量等方法对微球突释的影响。 The progress of controlling strategies for initial burst release of sustained-release injectable microspheres loaded with proteins is reviewed. The effects of several methods including structure modification of drugs, characterization of polymer materials, additives in formulation, preparation, diameter and drug loading of microspheres, on the burst release of microspheres are discussed.
作者 谢兰桂 刘玉玲
机构地区 中国医学科学院中国协和医科大学药物研究所
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第9期639-643,共5页 Chinese Journal of Pharmaceuticals
关键词 蛋白质 缓释注射微球 突释 综述 protein sustained-release injectable microsphere burst effect review
分类号 R499 [医药卫生—康复医学]
  • 相关文献

参考文献19

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共引文献24

同被引文献69

  • 1周超,闫玉华.聚乳酸-乙醇酸共聚物合成与降解[J].生物骨科材料与临床研究,2006,3(5):50-53. 被引量：9
  • 2任海霞,朱家壁,汤玥.微球制剂的应用研究进展[J].药学进展,2007,31(2):59-63. 被引量：22
  • 3廖新梅,王捷.影响微球蛋白药物稳定性与释放的因素研究进展[J].医药导报,2007,26(5):527-529. 被引量：4
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引证文献6

二级引证文献16

中国医药工业杂志
2006年 第9期

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