生长激素在大面积深Ⅱ度烧伤患者中的应用

The use of growth hormone in the treatment of patients with the second degree burns wound

目的探讨重组生长激素(rhGH)对大面积深Ⅱ度烧伤患者的血浆总蛋白、白蛋白及创面愈合的影响。方法将38例大面积烧伤患者随机分为重组人生长激素组和对照组各19例,在常规治疗的基础上,重组人生长激素组伤后5d开始加用rhGH,给予剂量0．2U·kg^(-1)·d^(-1),疗程14d,比较两组血浆总蛋白、白蛋白浓度、创面愈合的时间及愈合后瘢痕的情况。结果重组人生长激素组血浆总蛋白、白蛋白浓度明显增高,创面愈合时间提前5d,瘢痕增生明显减轻。结论rhGH能有效促进大面积烧伤患者血浆蛋白质的合成,加速烧伤创面的愈合,减少瘢痕的增生。

Objective To explore the effects of recombinant human hormone（rhGH） on the plasma total protein,plasma albmin, healing of wound surfaces in patients with the second degree burns wound. Methods 38 patients with the second degree burns wound were divided into treatment group and control group randomly. All the patients were subject general. 19 patients in the treatment group were given rhGH in a dose of 0.2U/kg for 14 days beginning from postoperative 5 days. The plasma total protein concentration, plasma albumin concentration, healing rat of wound surface and scar of patients of the two group were compared. Results The plasma total protein concentration plasma albumin concentration of the treatment group were significantly in creased,the scar hyperplasia of the treatment group were significantly mitigated and the healing time of wound surfaces of the treatment group were significantly shortened. Conclusion rhGH is found to promote protein anabolism and shorten the healing time of wound surfaces and mitigate the scar hyperplasia patients with the second degree burns wound.