SPECT肝细胞显像评价肝硬化程度

Evaluation of degree of hepatocirrhosis with liver cell magong by SPECT

目的评价肝硬化患者的肝细胞功能及肝硬化程度。方法对30例肝硬化患者及15例正常对照组,进行肝胆动态显像,通过三室模型获得肝细胞摄取、排泄功能的放射性-时间曲线,计算肝细胞摄取和排泄等功能指标。结果肝硬化组高峰时间、平均残存时间均显著高于正常对照组(均P＜0．01)；肝硬化组与正常组比较高峰值摄取指数、摄取斜率、排泄斜率均显著降低(均P＜0．01)。结论肝细胞显像是一种灵敏评价肝细胞代谢功能的无创性方法,可用于分析肝硬化程度。

Objective To evaluate the damaging degree of hepatic cell in the patients with hepatocirrhosis. Methods 25 cases of hepatocirrhosis and 13 cases of nornaal controls were performed the dynamic imaging with 99mTc-EHIDA. By the three compartmental model configurations, the time-activity curers of the liver cell, and the function indexes liver cell extraction and excretion were calculated. Results The peak time and mean residence time in the hepatocirrhosis group were higher than those in the normal controls（ P〈 0.01 ）. Compared to normal controls, the peak value, index of uptake, take slope, and excretion slope of the hepatocirrhosis were all lower（ P 〈 0.01 ）. Conclusion Liver cell imaging is a better method for reflecting the change of liver cell function,and may be used to analyse the degree of hepatocirrhosis.