苦参素注射液对化疗所致肝损害的保护作用

The protecting effects of matrine on chemotherapy related hepatic lesion,a retrospective clinical analysis

目的探讨苦参素对化疗所致肝损害的肝脏保护作用及其可能作用机制。方法回顾性对比在化疗基础上加用或不加用苦参素的化疗患者在化疗期间肝损害发生率及严重程度,并分析该药对乙肝病毒(HBV)感染和非感染患者化疗相关肝损害疗效的差异。结果苦参素治疗组肝损害的发生率和严重程度均显著低于对照组；对照组HBV感染者肝损害的发生率和严重性显著高于非感染者；而苦参素治疗组HBV感染及非感染者肝损害的发生率和严重程度差异无统计学意义。结论苦参素辅助治疗对化疗相关肝损害具有一定的保护作用。

Objective To evaluate the protecting effects of matrine on chemotherapy related hepatic lesion and its possible mechanism. Methods The positive rate and severity of hepatic lesion were compared between patients being treated with or without matrine during chemotherapy processes. Furthermore, the difference of liver protecting effect of this Chinese medicine between hepatitis B virus（HBV） infection chemotherapy patients and disinfection patients were also analyzed. Results Both the rate of hepatic lesion and level of ALT in matrine treated group were much lower .than those in untreated group in chemotherapy patients. The rate of hepatic lesion and level of ALT in HBV infection patients were higher than those in HBV disinfection patients in untreated group,while the significant difference of these two parameters between HBV infection patients and disinfection patients were disappeared in matrine treated group. Conclusion Matrine has hepatic protecting effect in chemotheranv related liver lesion.