摘要
目的:以高脂饲料配方建立青春期单纯性肥胖雄性大鼠模型。方法:21d龄雄性清洁级SD大鼠随机分为对照组(n=28只,喂普通饲料)和实验组(n=45只,喂高脂饲料)。观察比较3-6周末(即鼠龄函9周)大鼠的体质量、Lee's指数、体长和附睾周围脂肪重量。结果:喂养后第3-6周末实验组体质量、Lee’s指数和附睾周围脂肪重量均高于对照组(P〈0.01);第3周末实验组体质量已明显超过对照组(超重23.0%),随着大鼠周龄的增加,肥胖程度也在逐渐加重,至第6周末时体质量进一步超过对照组(超重26.6%);实验组肥胖鼠29只,非肥胖鼠16只。结论:以高脂饲料喂养的青春期大鼠可致单纯性肥胖。
Objective: To explore the establishment of diet-induced obesity model in pubertal male rats with high fat diet. Methods: Twenty-one-day-old male SD rats were randomly divided into the control group( n = 28)with common diet and the experimental group( n = 45)with high fat diet. Then the body weight, Lee's index and body length were measured after feeding 3-6 weeks (the rats age were 6-9 weeks old at last). Results: Compared with the control group, the body weight, Lee's index and the fat of epididymis in experimental group increased obviously( P 〈 0.01). The body weight in experimental group was higher 23 % than that in control group at 6 weeks old. With the development of obesity, the body weight of obese rats was over 26.6 % more than that of the control group in the end of experiments. In experimental group, there were 29 obese rats and 16 no obese rats. Conclusion: The high fat diet can induce obesity in pubertal rats.
出处
《汕头大学医学院学报》
2006年第3期160-161,164,共3页
Journal of Shantou University Medical College