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阿尔茨海默病IL-6和CD_4^+T细胞的研究进展 被引量:8

The Progress of Interleukin-6 and CD_4^+ Thymocyte Cell in Alzheimer Disease
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摘要 阿尔茨海默病(AD)是一种由多个原因引起并涉及多种发病机制的异质性疾病。研究表明炎症和免疫功能紊乱可能参与了AD的发生和发展。本文就白细胞介素-6(interleukin-6,IL-6)和CD+4T细胞的理化性质及其在AD中的变化进行阐述。 Alzheimer disease(AD) is a kind of disease with heterogeneity, whieh eaused by many factors and involved in many pathogenesis. Some studies have shown that inflammation and immune funetion disorder might partieipate in the oceurrenee and development of AD. In this article, we describe physieo-ehemieal property of interleukin-6(IL-6) and CD4 positive thymoeyle cell as well as theirs ehanges in AD.
出处 《医学综述》 2006年第18期1110-1112,共3页 Medical Recapitulate
基金 广西自然科学基金(桂科自0542091)
关键词 阿尔茨海默病 白细胞介素-6 CD4^+T细胞 Alzheimer disease Interleukin-6 CD4 positive thymocyte cell
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  • 1Wood JA,Wood PL,Ryan R,et al.Cytokine indices in Alzheimer's temporal cortex:no changes in mature IL-1 beta or IL-1RA but increaszs in the associated acute phase proteins IL-6,alpha 2-macroglobulin and C-reactive protein[J].Brain Res,1993,629(2):245-252.
  • 2Vandenabeele P,Fiers W.Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?[J].Immunol Today,1991,12(7):217-219.
  • 3Czlonkowska A,Kurkowska-Jastrzebska I.The role of inflammatory reaction in Alzheimer's disease and neurodegenerative processes[J].Neurol Neurochir Pol,2002,36(1):15-23.
  • 4Fattori E,Lazzaro D,Musiani P,et al.IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage[J].Eur J Neurosci,1995,7(12):2441-2449.
  • 5Tehranian R,Hasanvan H,Iverfeldt K,et al.Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576[J].Neurosci Lett,2001,301 (1):54-58.
  • 6吴传深,周东丰,管振全.血浆IL-6水平与阿尔茨海默病[J].中国神经免疫学和神经病学杂志,2003,10(2):87-89. 被引量:8
  • 7Sala G,Galimberti G,Canevari C,et al.Peripheral cytokine release in Alzheimer patients:correlation with disease severity[J].Neurobiol Aging,2003,24(7):909-914.
  • 8郭峰,屈秋民,韩建峰,乔晋,杨华,武成斌.阿尔茨海默病患者血清IL-1β,IL-6含量测定及其意义[J].第四军医大学学报,2004,25(16):1496-1498. 被引量:9
  • 9吴赛珠,谭家余,周忠江,周可祥,容志毅.性激素通过影响血脂、细胞免疫功能及氧化/抗氧化系统影响衰老[J].岭南心血管病杂志,2004,10(1):10-16. 被引量:9
  • 10Shalit F,Sredni B,Brodie C,et al.T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease[J].Clin Immunol Immunopathol,1995,75 (3):246-250.

二级参考文献47

  • 1侯也之.老年期痴呆外周血T淋巴细胞亚群的测定(摘要)[J].中华神经精神杂志,1991,4:206-206.
  • 2[1]Strauss S,Bauer J,Ganter U,et al. Detction of interleukin-6 and alpha-2 macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients[J]. Lab Invest, 1992,66(2):223-230.
  • 3[2]Huell M,Strauss S,Volk B,et al. Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients[J]. Acta Neuropathol(berl), 1995,89(6):544-551.
  • 4[3]Bonaccorso S,Lin A,Song C,et al. Seroto-nine-immune interactions in elderly volunteers and in patients with Alzheimer's disease DAT: lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT[J]. Aging (Milano), 1998,10: 316-323.
  • 5[4]Angelis P,Scharf S,Mander A,et al. Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease[J]. Neurosci Lett, 1998,244(2):106-108.
  • 6[5]Alvarez XA,Franco A,Fernandez-Novoa F,et al. Blood levels of histamine, IL-1 beta and TNF-alpha in patients with mild to moderate Alzheimer's disease[J]. Mol Chem Neuropathol, 1996,29:237-252.
  • 7[6]McGeer PL,Schulzer M,McGeer EG.Arthritis and anti-in-flammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiological studies[J]. Neurology, 1996,47:425-432.
  • 8[7]Mrak RE,Sheng JG,Griffin ST.Glial cytokines in Alzheimer's disease: review and pathogenetic implications[J]. Hum Pathol, 1995,26:816-823.
  • 9[8]Hampel H,Schoen D,Schwarz MJ,et al. Interleukin-6 is not altered in cerebrospinalfluid of first-degree relatives and patients with Alzheimer's disease[J]. Neurosci Lett, 1997,228:143-146.
  • 10[9]Lanzrein AS,Johnston CM,Perry VH,et al. Longitudinal study of inflammatory factors in serum, cerebrospinalfluid,and brain tissue in Alzheimer's disease: interleukin-beta1, interleukin-6, interleu-kin-1 receptor antagonist,tumor necrosis factor-alpha,the soluble tumor necrosis factor receptors Ⅰ and Ⅱ, and alpha1-antichymotrypsin[J]. Alzheimer Dis Assoc Disord, 1998,12:215-227.

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