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抗甲状腺药物对^(131)I治疗甲状腺功能亢进症疗效的影响 被引量：2

Effect of antithyroid drugs on the efficacy of ^(131)I in the treatment of hyperthyroidism
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摘要 131I是治疗甲状腺功能亢进症(甲亢)的主要药物之一,治疗前应用硫氧嘧啶类药物如丙硫氧嘧啶可能会降低131I治疗甲亢的治愈率,咪唑类药物如甲巯咪唑则不会影响其疗效。131I治疗甲亢后应用丙硫氧嘧啶或甲巯咪唑对131I疗效的影响尚有争议之处。抗甲状腺药物影响131I疗效的机理可能在于改变了131I的有效半衰期和(或)甲状腺对131I的摄取率。 ^131Ⅰ plays an important role in the treatment of hyperthyroidism. Propylthiouracil, which is used before ^131Ⅰ, can reduce the efficacy of ^131Ⅰ. However, methimazole does not. There exits contrary ideas about whether propylthiouracil and methimazole used after ^131Ⅰ might influence its efficacy. Antithyroid drugs may influence the efficacy of ^131Ⅰ, the possible mechanism might be that antithyroid drugs change the effective half-time and （or） uptake of ^131Ⅰ.
作者 张林 安振梅
机构地区 四川大学华西医院实验医学科激素检测室
出处 《国际内分泌代谢杂志》 2006年第5期342-343,350,共3页 International Journal of Endocrinology and Metabolism
关键词 抗甲状腺药物 放射性碘 甲状腺功能亢进症 Antithyroid drugs ^131Ⅰ Hyperthyroidism
分类号 R581.1 [医药卫生—内分泌]
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参考文献17

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二级参考文献9

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国际内分泌代谢杂志
2006年 第5期

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