新生儿缺氧缺血性脑病血浆TNF-α水平变化及意义

CLINICAL SIGNIFICANCE OF PLASMA TNF-α IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY

目的探讨新生儿缺氧缺血性脑病(HIE)病儿血浆肿瘤坏死因子-α(TNF-α)水平的变化及其临床意义。方法应用ELISA法分别检测42例HIE病儿急性期、恢复初期及20例正常对照组儿童血浆TNF-α水平。结果HIE病儿急性期血浆TNF-α水平明显高于正常对照组(t=3.104,P<0.01);中、重度HIE病儿TNF-α水平明显高于轻度HIE病儿(t=2.535,P<0.05)。结论TNF-α在HIE的发病机制中可能起重要作用。

Objective To investigate the clinical significance of the plasma level of tumor necrosis factor-alpha （TNF-α） in neonates with hypoxic ischemic encephalopathy （HIE）. Methods Plasma TNF-α levels were measured by ELISA in 42 neonates with HIE at acute phase and early-recovery phase and 20 normal controls. Results The TNF-α level in acute phase was significantly higher than that in the controls （t=3. 104, P〈0.01）, TNF-α in moderate and severe patients was higher than that in mild ones （t=2. 535, P〈0.05）. Conclusion Plasma TNF-α might play an important role in the pathogenesis of hypoxic ischemic encephalopathy.