患肢动脉内注射r-SK对下肢深静脉血栓形成的效果

EFFICACY OF RECOMBINANT STAPHYLOKINASE INJECTION FOR DEEP-VEIN THROMBOSIS

目的探讨患肢动脉注射重组链激酶(r-SK)治疗下肢深静脉血栓形成的安全性和有效性。方法对31例下肢深静脉血栓形成病人,从健侧股动脉穿刺插管至患侧髂股动脉内。r-SK经下肢动脉注入,并动脉内保留导管,每日溶栓。结果病程在2周内病人,痊愈2例,显效10例,有效4例;病程在2周以上的病人,显效5例,有效8例,无效2例。病程在2周内的病人疗效明显好于病程在2周以上的病人(uc=2.33,P<0.05)。治疗过程中无出血并发症发生。结论经患肢动脉注射r-SK溶栓治疗下肢深静脉血栓形成安全、有效,而且溶栓时间越早效果越好。

Objective To evaluate the therapeutic effect and safety of recombinant staphylokinase （r-SK） injection in affected-limb artery for deep-vein thrombosis （DVT）. Methods Thirty one patients with DVT were treated. An intubation was done through unaffected-limb femoral artery to affected-side iliofemoral, and r-SK injected by way of the lower-limb artery. The catheter was retained, and thrombolysis given everyday. Results The outcomes were as follows： for those the course within two weeks, two cured; ten marked response; four response, for those more than two weeks, five showed marked response; eight response, two no response. The results of two groups were significantly different （uc = 2.33, P〈0.05）. No bleeding was observed during the treatment. Conclusion r-SK injection through affected-limb artery is safe and effective for lower-limb DVT. The earlier the treatment, the better the outcomes.