摘要
目的评估肾移植术前、术后应用重组人红细胞生成素（rHuEPO）对移植肾功能的影响，以及对肾移植术后贫血的纠正作用。方法病人随机分为3组。A组术前术后均未接受rHuEPO治疗，B组在肾移植术前接受rHuEPO治疗，C组肾移植术后早期接受rHuEP0治疗，当红细胞压积（Hct）〈0．30时开始应用rHuEPO治疗。结果rHuEPO治疗后的血红蛋白（Hb）均明显升高，以C组最高（F=43．51、88．79，q=3．27～18．85，P〈0．05）；B、C组术后肾功能延迟恢复和急性排斥反应的发生率与A组比较差异无显著性（P〉0．05）。结论在肾移植手术后早期应用rHuEPO对纠正贫血是有益的，而且不会增加肾功能延迟恢复和急性排斥反应的发生率。
Objective To assess the effects of pre- or postoperative application of recombinant human erythropoietin （rHuEPO） on graft function and postoperative anemia in patients undergoing renal transplantation. Methods The patients were randomly divided into three groups： group A, no rHuEPO was used, group B, preoperative rHuEPO, and group C, postoperative rHuEPO, in which, rHuEPO was given when HCT was less than 0.30 postoperatively. Results Hb was significantly increased after rHuEPO treatment （F=43.51,88.79,q=3.27-18.85; P〈0.05）, group C being the highest. There was no difference between the three groups in terms of delayed renal function and acute rejection. Conclusion The use of rHuEPO during the early stage after transplantation is helpful in the correction of anaemia without increasing the incidence of acute rejection and delayed graft function.
出处
《齐鲁医学杂志》
2006年第4期347-348,共2页
Medical Journal of Qilu
关键词
红细胞生成素
重组
肾移植
贫血
ervthroooietin, recombinantt kidnev transolantation
anaemia
