妊娠糖尿病孕妇血管性假血友病因子检测的意义

Changes of von Willebrand factor in women with gestational diabetes mellitus

目的探讨妊振糖尿病(GDM)孕妇血浆血管性假血友病因子(vWF)变化及意义。方法采用酶联免疫吸附测定(ELISA)法检测20例GDM、32例正常妊娠及22例非妊娠妇女血浆vWF浓度。结果与非妊娠对照组相比,正常妊娠组空腹血浆vWF浓度明显升高,GDM组血浆vWF浓度又显著高于正常妊娠组及非妊娠对照组[(329.43±83.67)%vs(205.14±49.25)%vs(108.62±37.58)%],其差异均有统计学意义(P<0.001)。结论GDM孕妇存在较正常孕妇更为严重的血管内皮功能受损。

Objective To investigate the level of plasm von Willebrand factor（vWF） in patients with gestational diabetes mellitus（GDM）. Methods The level of plasm vWF was measured by enzyme linked immunosorbent assay in 20 GDM women,32 normal pregnancy women, and 22 non-pregnancy women. Results The fast plasm level of vWF in normal pregnancy （205.14±49.25）% was obviously higher than that of nen-pregnancy group （108.62 ±37.58）%, and the level of vWF in GDM （329.43 ±83.67）% group was obviously higher than that of normal pregnancy （205.14±49.25） %, there were significance difference among them （ P 〈 0. 001 ）. Conclusion The blood vessel endothelium was damaged more seriously in GDM women than in normal pregnancy women.