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PTEN在胃黏膜癌变过程中的表达及意义 被引量:1

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出处 《临床荟萃》 CAS 北大核心 2006年第18期1314-1315,共2页 Clinical Focus
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  • 1Dian-Chun Fang Shi-Ming Yang Xiao-Dong Zhou Dong-Xu Wang Yuan-Hui Luo Department of Gastroenterology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China.Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer[J].World Journal of Gastroenterology,2001,7(4):522-526. 被引量:35
  • 2[1]Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH,Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R,Swedlund B, Teng DH, Tavtigian SV. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15:356-362
  • 3[2]Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J,Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC,Ittmarn M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN,a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275:1943-1947
  • 4[3]Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 1997; 57:2124-2129
  • 5[4]Cantley LC, Neel BG.New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999; 96: 4240-4245
  • 6[5]Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 1998; 95:15587-15591
  • 7[6]Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,trisphosphate and Akt/protein kinase B signaling pathway.Proc Natl Acad Sci U S A 1999; 96:6199-6204
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