病理性瘢痕组织中c-fos和5-HT表达及与其增生和痛痒的关系

EXPRESSIONS OF c-fos AND 5-HT IN ABNORMAL SCARS AND THEIR RELATIONSHIP WITH HYPERPLASIA,ITCH AND PAIN

目的通过对病理性瘢痕组织中c—fos和5-HT表达变化的研究，探讨其与病理性瘢痕痛痒和增生的关系。方法利用免疫组化方法检测病理性瘢痕和正常皮肤中c—fos和5-HT的表达情况。结果痛痒的病理性瘢痕组织中c—fos、5-HT的表达显著高于正常皮肤组织和非痛痒的瘢痕组织（F=19．86、17．61，q=5．43～8．84，P（0．01）；非痛痒的瘢痕组织中c—fos的表达显著高于正常皮肤（q=3．41，P〈0．01），而5-HT表达无明显差异（P〉0．05）。结论c-fos、5-HT表达增高可能导致病理性瘢痕临床痛痒症状的发生，c—fos表达增高可能与病理性瘢痕的形成、发展有关。

Objective To study the expression of two mediums, i.e. c-los and 5-HT, in abnormal scars and their relationship with hyperplasia, itch and pain. Methods The immunohistochemistry method was applied to study expressions of c-fos and 5- hydroxytryptamine （5-HT） in pathologic scars and normal skin. Resglts In the itching or painful scars, c-fos and 5-HT expressions were all significantly higher than those in non-itching or painful scars and normal skin （F= 19.86,17.61;q= 5.43- 8. 84; P〈0.01）; the expression of c-fos in non-itching or painful scars was higher than that with normal skin （q= 3.41, P〈 0.01）, while 5-HT expression was of no difference （P〉0.05）. Conclusion The high expressions of c-fos and 5-HT may induce itching and painful symptoms of abnormal scars, and c-fos may contribute to the formation of the abnormal scars.