摘要
目的 探讨不稳定型心绞痛（UA）病人血管性血友病因子（VWF）与可溶性补体激活产物（sC5b-9）水平变化及其与心肌缺血的关系。方法 采用酶联免疫吸附法（ELISA），对61例健康人（对照组）和82例UA（自发性心绞痛30例，心肌梗死后心绞痛28例，恶化型心绞痛24例）病人血浆VWF、sC5b-9浓度的变化进行了检测。结果UA病人血浆VWF、sC5b-9浓度明显高于对照组，差异有极显著性（t＇=15．277～26．210，P〈0．001）；心绞痛发作时VWF、sC5b-9浓度增高较缓解后更明显（t’=24．462、5．902，P〈0．001）；心绞痛发作时和缓解后sC5b-9与VWF浓度呈正相关（R=0．804、0．782，p〈0．001）；不同类型的心绞痛发作时和缓解后sC5b-9、VWF浓度差异亦具有显著性（F=21．708～152．410．q=3．917～25．630，P〈0．01）；自发性心绞痛病人各指标增高较心肌梗死后和恶化型心绞痛更明显。结论 急性心肌缺血与VWF和sC5b9异常有一定关系。
Objective To explore the changes of Von Willebrand factor （VWF） and complement activation component （sCSb-9） ,and the correlation of VWF and sC5b-9 with acute myocardial ischemia. Methods Using enzyme linked immunosorbent assay （ELISA）,the changes of VWF and sC5b-9 were measured in 82 patients with unstable angina （UA）, i.e. spontaneous angina （30 cases）, post infarction angina （28）, and progressive angina （24） , as well as in 61 healthy controls. Results The levels of VWF and sC5b-9 were significantly higher in UA patients than those in controls （t＇=15. 277-26. 210,P〈0. 001）. The increase of VWF and sCSb-9 during the attack were more obvious than those in remission （t＇=24. 452,5. 902;P〈0. 001）. VWF correlated positively with sC5b-9 （r=0.804,0.782;P〈0.001）. In different types of angina, there were significant differences be tween VWF and sC5b-9 during angina attack and remission （F=21. 708-152. 410,q=3. 917-25. 630,P〈0.01） ,and increase of all the markers in spontaneous angina were more obvious than those in progressive and post-infarction angina. Conclusion Acute myocardial ischemia has definite relation with abnormal VWF and sC5h-9.
出处
《青岛大学医学院学报》
CAS
2006年第3期189-190,193,共3页
Acta Academiae Medicinae Qingdao Universitatis
