复方扶芳藤合剂HPLC指纹图谱共有模式的建立及其在制剂质量控制中的应用

Application of HPLC fingerprint in quality control of Fufangteng combination formula

目的:建立复方扶芳藤合剂的HPLC指纹图谱共有模式,为该制剂的质量控制提供新的方法。方法:采用HPLC分析方法,选择10批合格样品的HPLC指纹图谱,进行峰位校正,使谱峰匹配,建立复方扶芳藤合剂对照用HPLC指纹图谱共有模式。结果:该指纹图谱共有模式可以较好地区分合格与不合格产品。结论:HPLC指纹图谱质量控制方法为复方扶芳藤合剂的质量控制提供了更全面的信息。

Objective： To establish the characteristic mode of HPLC fingerprint of Fufangteng combination formula for the quality control of this medicine. Method： 10 batch certified products were selected to establish the characteristic mode of HPLC fingerprint of Fufangteng combination formula by chromatographic pattern matching and retention time correction. Result： This characteristic mode of HPLC fingerprint can clearly differentiate the eligible Fufangteng products from the unqualified products. Conclusion： This method can provide thorough information for the quality control of Fufangteng combination formula.