水基稳定分散的靶向药物用纳米Fe_3O_4的制备

Preparation of Water-based Stabilized Dispersion of Nanon Fe_3O_4 Used in Target-orientation Drug

用于靶向抗癌药物微球的磁性Fe3O4颗粒必须具有合适的粒径,并且保证其不发生团聚。采用化学共沉淀法制备了纳米Fe3O4磁性颗粒,XRD分析证实了产物的主要组成为立方晶系Fe3O4;粒度分析表明,产物平均粒径16.3 nm左右,粒径分布宽度约5.8 nm;采用高分辨透射电镜(HRTEM)观察产物形貌,证明纳米Fe3O4胶体溶液中磁性粒子呈球形分布,且未发生明显的团聚现象;测得Fe3O4胶体溶液ζ电位为+39.9 mV,颗粒吸附溶液中的C l-离子形成了吸附双电层结构,较强的静电排斥力阻止纳米粒子团聚,因此,制得的纳米Fe3O4胶体溶液具有很强的分散稳定性。

Fe3O4 magnetic nanoparticles for tumor target therapy must have suitable diameter and must not reunite. In this work Fe3O4 magnetic nanoparticle were prepared by liquid-phase coprecipitation. The product is cubic crystalline nanon Fe3O4 as approved by XRD. Granularity analysis showed that the average size of nanoparticle is 16. 3 nm. Characterizations of Fe3O4 was done by TEM that the magnetic nanoparticles in the colloidal solution are spherical and do not coacervate. Zeta-potential of the Fe3O4 particles is ＋ 39.9 mV. The nanoparticles can adsorb CI^-to form electric double-layer and the strong repulsion between them prevents the nanoparticles to reunite. Therefore the nanon Fe3O4 colloidal solution has high dispersion stability.