壳聚糖及其衍生物与碘的络合物的抑菌性质研究

Study of Characteristics of Bacterial Inhibition by Complex Compounds of Chitosan and Its Derivatives with Iodine

利用壳聚糖(CTS)、水杨醛改性壳聚糖(S-CTS)和还原水杨醛改性壳聚糖(RS-CTS)与碘以不同质量比制备络合物,通过碘量法测络合物的摩尔比,UV光谱和IR光谱对络合物进行了表征。考察了CTS和RS-CTS与碘络合物的抑菌性质。结果表明,壳聚糖及其衍生物与碘络合物摩尔比(壳聚糖及其衍生物结构单元与碘之比)分别为:n(CTS)∶n(I2)=1∶0.38,n(S-CTS)∶n(I2)=1∶0.85,n(RS-CTS)∶n(I2)=1∶0.73。CTS和RS-CTS与碘的络合物对金黄色葡萄球菌抑菌敏感度为高度敏感。

The complex compounds were prepared by chitosan （CTS） and its derivatives （ S - CTS, RS - CTS） with iodine in different proportions. The mole ratio of the complex compound （ structural unit of chitosan to iodine） was investigated by iodimetry. Bacterial inhibition of the complex compounds was also tested. It is found that the mole ratios are n （CTS） ：n （ I2 ） = 1：0.38, n （ S - CTS） ： n （ I2 ） = 1：0. 85 and n（ RS - CTS） ：n（ I2 ） = 1：0.73. According to the antibacterial assays, bactericidal activity of the complex compounds of CTS and RS - CTS with iodine toward Staphylococcus aureus is very significant.