关附甲素在犬体内的药动学-药效学结合模型分析

Combined Pharmacokinetic-Pharmacodynamic Model Analysis of Guanfu Base A In Dogs

用药动学-药效学结合模型,对犬静脉推注关附甲素后,进行了药代动力学和药效动力学分析。以QTc延长百分率为效应指标,关附甲素的E_(max)、S、K_(co)和EC_(50)分别为1.11±0.01,1.06±0.43,0.097±0.046 min^(-1)和1.50×10^(-6)±0.92×10^(-6)μg/ml。

The pharmacokinetic and pharmacodynamic profiles of Guanfu base A were analyzed by integrated PK-PD model following iv to dogs. The percentage of QTc intervcal prolongation was recorded as effect index. The values of E_(max), S, K_(e0) and EC_(50) for Guanfu base A were 1.11±0.01, 1.06±0.43, 0.097±0.046 min^(-1) and 1.50×10^(-6)±0.92×10^(-6)μg/ml respectively