阿比朵尔对大鼠的长期毒性

Long-term toxicity of arbidol in rats

目的:观察阿比朵尔对大鼠的长期毒性反应。方法:96只Wistar大鼠,雌雄各半,随机分成4组,即1200,350和100 mg·kg-1剂量组和对照组,连续灌胃给药4周,按常规方法观察动物一般状况、体重、摄食量、血液学、血液生化、脏器重量系数及组织病理学改变。结果:阿比朵尔未引起动物死亡。给药期:高剂量组雌鼠第1-4周体重明显低于对照组,并有6只动物陆续出现明显掉毛;高剂量组雄鼠第2-4周体重明显低于对照组,并有4只动物陆续出现明显掉毛;其他指标与对照组比较无明显差异。低剂量组和中剂量组各项指标与对照组比较均无明显差异。恢复期:高剂量组雌鼠第1周体重仍明显低于对照组,其他各剂量各项指标与对照组比较均无明显差异。结论:大鼠口服阿比朵尔4周,350 mg·kg-1为安全剂量,1 200 mg·kg-1对大鼠生长有可逆性抑制作用。

Objective： To study the long-term toxicity of arbidol in rats. Methods： 96 Wistar rats were randomly divided into four groups, each group orally received the dose of arbidol of 0, 100, 350 or 1 200 mg·kg^-1 for 4 weeks. The toxicity of arbidol to rats was assessed based on the status changes of growth rate, appetite,blood hemo and biochemical outcomes, organ weight index and histopathologic profile in post-dosing. Results： No rats＇ death was found. The depilation and reduction of rats＇ weight were associated with the dosing of 1 200 mg·kg^-1 the rats received. No significant differences of other physiological parameters were seen in the rats treated with 100 and 350 mg·kg^-1. In the period of recovery post treatment, the abnormal physiological outcomes were back to normal. Conclusion： The safe dosage of arbidol to rats was 350 mg·kg^-1 The inhibition of rats＇ growth by 1 200 mg·kg^-1 of arbidol was reversible.