pH值调节法制备壳聚糖空白微球

Preparation of chitosan microspheres by changing pH

目的:介绍一种壳聚糖空白微球的制备方法。方法:将溶有氨水的异丙醇加入到壳聚糖乳液中,使得壳聚糖液滴由酸性变为碱性,壳聚糖凝固析出。结果:制得了粒径在3—8μm左右,粒径分布均匀的壳聚糖微球。结论:使用改变pH值的方法来制备壳聚糖微球,避免了传统固化剂的使用及其缺点。

Objective： To study a pH method for the preparation of chitosan microspheres. Methods： The isopropanol dissolved in ammonia solution was dropped into chitosan latex, crystallizing chitosan microspheres in the alkaline environment. Results： The homogenous particle size of the chitosan microspheres was 3 ～8μm. Conclusion： This pH method to prepare the microspheres may overcome the use and disadvantage of traditional condensers.