曲唑酮治疗苯二氮类依赖患者疗效观察

Clinical Observation of Trazodone in Treatment of Anxiety with Addiction to Benzodiazepines

目的 观察对抗焦虑药苯二氮[艹卓]类（BDZ）依赖的患者使用曲唑酮替代的疗效。方法 符合DSM-Ⅲ-R诊断标准的15例BDZ依赖患者住院治疗2周，给予曲唑酮（50～150mg，1次／d），并快速减少其BDZ类药物的每日用量。之后每周进行一次门诊检查，随访3个月，剂量根据个人情况增减。结果 在BDZ药物逐渐减量阶段很少出现戒断现象，在随访的3个月中，所有患者保持停用BDZ类药物且没有滥用曲唑酮现象，同时焦虑、抑郁症状明显改善。汉密尔顿焦虑量表（HAMA）评分从12．5降为5．3（P〈0．05），汉密尔顿抑郁量表（HAMD）评分从11．8降为4.9（P〈0．05）。结论 曲唑酮对BDZ类药物有滥用危险的焦虑患者可作为长期治疗的重要替代药，且曲唑酮没有潜在的滥用可能性。

Objective To evaluate the therapeutic effect of trazodone in the treatment of anxiety with addiction to benzodiazepines （BDZ）. Methods 15 patients meeting DSM - Ⅲ- R diagnostic criteria with BDZ addiction were assigned to trazodone （50 - 150mg qd） of 2 weeks, with rapid reducement of the daily dose of BDZ. Followed by weekly outpatient examination and dosage adjustment in accordance with each patient＇s condition for next 3 months. Results There were few withdrawal reaction during the phase of gradually reducement of BDZ. None of the patients used BDZ or abused trazodone during the follow - up periods of 3 months, and the symptoms of anxiety and depressant advanced. HAMA Score was reduced from 12. 5 to 5.3 （ P 〈 0. 05 ）, and HAMD Score from 11.8 to 4. 9 （ P 〈 0. 05）. Conclusion Trazodone can be an important drug in the treatment of anxiety with addiction to BDZ for long -term treatment without potential possibility of abusement.