纳络酮治疗新生儿缺氧缺血性脑病临床观察

Naloxone for treatment of hypoxic ischemic encephalopathy of newborn babies

目的观察应用纳络酮治疗中重度新生儿缺氧缺血性脑病(HIE)的疗效。方法将96例中重度HIE病儿随机分成治疗组和对照组各48例,治疗组在传统治疗的基础上加用纳络酮,并与对照组比较。结果治疗组总有效率79.2%,对照组总有效率43.9%,差异有统计学意义(P<0.05)。结论纳络酮治疗HIE疗效显著,且未见副作用发生。

Objective To observe the clinical effects of naloxone on the treatment of hypoxic ischemic encephalopathy （HIE） of newborn babies. Methods 96 serious HIE patients were randomly put into the treatment group and the control group with each group having 48 cases. The treatment group was given naloxone in addition to conventional therapeutic protocols; whereas only conventional treatments were administered in control group. The effects were compared between the two groups. Results In the treatment group, the total effective rate was 79.2% ; whereas in the control group, the rate was 43.9%. The effects were significantly different between the two groups （P〈0.05）. Conclusion Naloxone is useful in the treatment of HIE, and no side effects are observed.