摘要
目的探讨安定溶液舌下给药治疗小儿惊厥的临床疗效及安全性。方法选择惊厥患儿92例,随机分为治疗组46例,舌下给药0.5mg/kg;对照组46例,直肠给药0.5mg/kg。比较两组控制惊厥显效率和总有效率及控制惊厥平均起效时间。同时观察治疗组的不良反应。结果治疗组显效率高于对照组(χ2=7.38,P=0.012),总有效率与对照组差异无统计学意义(χ2=0.548,P=0.714);治疗组平均起效时间较对照组短(t=5.42,P=0.000);治疗组除止惊后嗜睡、乏力外未见其它不良反应。结论舌下给药临床应用安全方便,止惊快速有效,值得临床推广。
Objective To evaluate the efficacy and safety of sublingual administration of diazepam solution to treat infantile convulsion. Methods Ninety-two cases of infantile convulsion were employed in our study. They were randomly divided into two groups. Patients in treatment group (n = 46)were given diazepam solution 0. 5mg/kg sublingually, while those in control group (n= 46)were given the same dose of diazepam solution per rectum. The effective rate, the time for the antispasmodic to take effect, and the adverse effects were compared between the two groups. Results The excellent effective rate was substantially higher in treatment group than control one (X^2= 7.38,P =0. 012). The total effective rate was roughly identical in the two groups (X^2=0. 548,P=0. 714). The time for the antispasmodic to take effect was shorter in treatment group than control one (t= 5.42,P= 0. 000) . No adverse effects were observed in the treatment group except drowsiness and debility. Conclusion Sublingual administration of diazepam solution is proven to be an effective, safe, and easy to use medication in the treatment of infantile convulsion, and therefore it is deemed eligible for extensively clinical use.
出处
《西部医学》
2006年第5期566-567,共2页
Medical Journal of West China
关键词
安定溶液
舌下给药
小儿惊厥
Diazepam
Sublingual administration
Infantile convulsion