雷帕霉素洗脱支架治疗冠心病的近期疗效研究

Short and mid-term outcomes of sirolimus-eluting stent implantation in coronary artery disease

目的评价冠心病患者接受雷帕霉素洗脱支架(SES)的近斯安全性及有效性。方法对160例接受雷帕霉素洗脱支架植入术患者实施即刻疗效和临床随访。结果160例中共处理病变210处,植入支架216枚。其中B2型以上复杂病变145处(69.0%),小管径支架(2.5mm^2.75mm)44例(27.5%),长支架58例(36.3%),术中无严重并发症发生,手术成功率100%。130例(81.3%)随访1~17个月,6例患者类似胸痛发作,其中3例复查了冠状动脉造影,无支架及节段内再狭窄,未发生心肌梗死及死亡。结论雷帕霉素洗脱支架治疗冠心病患者近期疗效安全有效。

Objective To evaluate the safety and efficacy of sirolimus-eluting stent （SES） implantation in treatment of coronary artery disease. Methods A series of 160 patients enrolled from November 2004 to May 2006 in our hospital were treated by SES implantation and the outcomes were evaluated thereafter. Results 210 lesions were treated by 216 stents, in which 145 belonged to complex lesions （69.0%） （Types B2 and C）, 44 cases（27.5%） were implanted with small caliber stents（2. 5mm-2. 75mm） and 58 cases（36. 3%） with long stents （〉20mm）. Patients recovered uneventfully after operation and no severe complications were noted during hospitalization and 1-17 month follow-up. The success rate of SES implantation was 100%. Six patients complained of chest pain after implantation, in whom 3 underwent coronary angiography and failed to find stent restenosis; moreover no acute myocardial infarction or death occurred in all the 6 cases. Conclusion The short-term therapeutic effect of SES implantation on coronary artery disease is corroborated safe and effective,