中药归经的形态学基础研究(二)

Morphological Foundation of Meridian Entry of Chinese Materia Medica (Part Two)

目的:研究中药归经的形态学基础。方法:采用14C-脱氧葡萄糖代谢测定等方法研究涵盖所有药性的60味中药,在一次用药2h、4h时,聚类分析不同归经对各组织器官机能的影响。结果:用药2h时,器官组织分为10类;4h时,器官组织分为9类,各归经变量之间具有最大的显著性差异,而器官组织形成的类别最少;一种归经可以作用于多个器官组织,不同归经可以作用于相同的器官组织;不同时间点同一归经作用的器官组织类别有所不同,中药归经的作用与解剖学脏器的联系具有时-效特点。结论:中药归经作用对象在不同的时间点有不同的形态学基础,其作用是通过多途径实现的;中医脏腑与解剖学器官组织之间不是单纯的一一对应关系,而是一种具有交叉重叠的网络关系。

Objective： To study morphological foundation of meridian entry of Chinese materia medica. Methods： Such method as ^14C-deoxyglycometabolism detection was adopted to observe the effects of 60 herbs with different meridian entry on the functions of organs and tissues at hour two and four after herbal administration. Results： There was a significant difference among meridian entry in extensive ranges of organs and tissues which were separated into 10 categories at hour two after administration, 9 categories at hour four after administration; one meridian entry might influence different organs and tissues, different meridian entry might influence the same organ and tissue. At different time, the same meridian entry might influence different organs and tissues. The action of meridian entry was provided with characteristic of time-effect. Conclusion： Meridian entry of Chinese materia medica has different morphological foundation at different time. There was no one-to-one relation, but interlaced meshwork between Zang-Fu, Jing-Luo of Traditional Chinese Medicine and anatomical organs or tissues.