从急性上感风热型急性期和痊愈期的呼吸道微生态变化探讨外感疾病的“正胜邪退”

Study on Vital Energy Increasing with Evils Decreasing in Exogenous Diseases from the Changing of Microbial Population at the Acute Stage and Recovery Stage of Acute Upper Respiratory Tract Infection

目的:探讨外感疾病中关于中医学“正胜邪退”的机制,以期发现病人由急性期向痊愈期转变时人体“邪正发病”、"正胜邪退"与微生态及免疫平衡相关性的某些规律。方法:选择急性上感风热型患者30例,对同一病例均进行急性期与痊愈期两次上呼吸道拭物标本和唾液标本采集,检测菌群密集度、菌群多样性、优势菌,以及黏膜免疫球蛋白SIgA。并设健康对照组30例。结果:患者在急性期口咽部菌群密集度、优势菌种类构成、黏膜免疫球蛋白SIgA含量与正常组有显著性差异(P<0.01或P<0.05),菌群多样性与正常组相比无显著差异;痊愈期与正常组相比无显著性差异。结论:外感疾病由急性期至痊愈期的过程,是“正胜邪退”的过程,也是人体微生态与免疫由非平衡恢复平衡的过程。

Objective： To study the mechanism of vital energy increasing with evils decreasing in TCM in exogenous diseases, expect to discover some rules of the relationship between the vital energy against evils, both vital energy increasing and evils decreasing, and the balance of microbial population and immunity. Methods： 30 patients with acute upper respiratory tract infection were included in the study, compared with normal group of 30 persons. The changing of the micro population （population density, population diversity, predominating population） and SIgA on both the acute stage and recovery stage were detected by assaying pharynx and saliva sample. Results： There were significant difference between normal and treatment group at the acute stage in population density, predominating population and SIgA （P 〈 0.01 or P〈 0.05）, and between the acute stage and the recovery stage of patients in population density and SIgA（P〈 0.05）. There was no difference in population diversity; significant difference was not observed between treatment at recovery stage and normal group. Conclusion： Theory of vital energy increasing with evils decreasing in TCM should include microbial population and immune in body from imbalance to balance.